Article: Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study.
Neither the amplitude nor the decay phase of the miniature postsynaptic currents (mPSCs) showed significant change after the various treatments.
Amplitude (control; pA)
Amplitude change (% of the control)
Decay tau (control; ms)
Decay tau change (% of the control)
E2
-31.6 ± 3.0
102.4 ± 5.3
9.7 ± 1.7
103.2 ± 18.1
Faslodex+E2
-27.8 ± 2.4
103.0 ± 2.2
7.1 ± 0.9
95.9 ± 20.1
AM251+E2
-24.7 ± 2.2
101.3 ± 3.5
8.6 ± 2.6
103.3 ± 28.5
THL+E2
-30.0 ± 4.3
93.8 ± 3.4
5.7 ± 1.2
104.7 ± 29.2
DPN
-36.6 ± 6.7
102.9 ± 5.1
14.1 ± 2.2
114.5 ± 11.3
PHTPP+E2
-26.6 ± 3.0
100.1 ± 4.0
9.5 ± 1.2
102.4 ± 22.4
AM251+DPN
-32.7 ± 10.6
97.1 ± 6.0
6.6 ± 1.3
128.4 ± 26.6
PPT
-28.7 ± 3.1
98.7 ± 6.7
12.9 ± 1.6
108.2 ± 15.8
G1
-33.0 ± 2.6
98.8 ± 2.2
6.0 ± 0.7
116.0 ± 19.3
The table shows the mean amplitude and decay tau before drug administration and the percentage change in these parameters resulting from the drug administrations.
